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Trimetazidine: A Comprehensive Guide to Managing Angina and Heart’s Health

Trimetazidine and Angina: An Evolving Landscape of Treatment

Trimetazidine, a member of the class of medications known as fatty acid oxidation inhibitors, stands as a crucial player in the realm of cardiac care. Primarily employed in the prevention and management of angina, this medication tackles the distressing symptoms associated with chest pain, often rooted in compromised blood supply and insufficient oxygen reaching the heart.


Angina, a discomforting manifestation arising from reduced blood flow and oxygenation to the heart, triggers distressing sensations in the chest. Trimetazidine steps in by bolstering the energy metabolism of heart muscle cells. This mechanism shields these cells from the detrimental impacts of diminished oxygen supply, effectively mitigating angina episodes. Over extended periods, consistent use of trimetazidine can significantly decrease the frequency of these distressing episodes, offering patients a better quality of life.

However, navigating the use of this medication requires careful consideration and adherence to guidelines. It’s imperative not to discontinue this medication without consulting a healthcare professional, as abrupt cessation might exacerbate the condition. Taking this medicine with or after food optimizes its efficacy and absorption.

If you forget this medication?

In the event of a missed dose, it’s advisable to take it as soon as remembered, unless it’s almost time for the subsequent scheduled dose. Doubling the dose to compensate for a missed one is not recommended.

Precautions Prior to Trimetazidine Intake

Before Commencing Trimetazidine:

Before initiating Trimetazidine, it’s crucial to consider the following precautions:

  • Allergic Reactions: Inform your healthcare provider if you have any allergies to this medication or its components.
  • Pregnancy and Breastfeeding: Disclose if you are pregnant, planning pregnancy, or currently breastfeeding.
  • Kidney Conditions: Notify your healthcare provider about any existing kidney issues.
  • Neurological Disorders: Share information regarding Parkinson’s disease, tremors, restless leg syndrome, or any related movement disorders you may have.
  • Medication and Supplements: Inform your healthcare provider about all medications you’re taking, encompassing supplements, traditional medicines, and herbal remedies.

RELATED ARTICLE: Trimetazidine

Understanding Potential Side Effects

Trimetazidine, like any medication, may elicit varying reactions in individuals. Here’s a breakdown of potential side effects:

  • Dizziness
  • Headache
  • Stomach Pain
  • Diarrhea
  • Indigestion
  • General Discomfort or Feeling Unwell
  • Vomiting
  • Rash
  • Itching
  • Hives
  • Weakness

This medication may induce dizziness, potentially impacting your ability to drive safely.

Rare Side Effects (Up to 1 in 1,000 People)
  • Rapid or Irregular Heartbeat (Palpitations)
  • Extra Heartbeats
  • Orthostatic Hypotension (Blood Pressure Drop When Standing, Leading to Dizziness, Lightheadedness, or Fainting)
  • Malaise (General Sense of Unwellness)
  • Dizziness or Flushing

RELATED ARTICLE: What Is Trimetazidine?

Targeted Treatment for Various Conditions


Trimetazidine addresses angina, characterized by chest discomfort resulting from insufficient oxygenated blood supply to the heart.

Heart Failure:

This medication assists in cases of heart failure, where the heart exhibits reduced pumping efficiency.

Peripheral Artery Disease (PAD):

Trimetazidine is beneficial in peripheral artery disease (PAD), marked by the constriction of blood vessels responsible for carrying blood from the heart to other body parts.

RELATED ARTICLE: What is Trimetazidine used for?

How to store this medication?

Storage and disposal guidelines play a vital role in ensuring medication safety. Trimetazidine should be stored in a cool, dry place away from direct sunlight and beyond the reach of children. Expired medications should be appropriately discarded by sealing them in a black trash bag before disposal in a designated manner, adhering to safety protocols.

Furthermore, acknowledging the collaborative efforts behind medication information fosters trust and reliability. The insights and guidance provided in this article stem from the collaborative work of the National Medication Information workgroup, uniting healthcare clusters, community pharmacies, and the Pharmaceutical Society of Singapore. However, it’s essential to note that this information might not encompass current drug availability details in various healthcare institutions or pharmacies. Hence, verification from respective institutions is strongly advised.



In conclusion, trimetazidine emerges as a crucial ally in managing angina and promoting heart health. Its efficacy, coupled with adherence to guidelines, prudent usage, and informed decision-making in collaboration with healthcare professionals, can significantly improve the quality of life for individuals grappling with cardiac challenges.

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